Gallia Academy Blue Devils
| Date | Opponent | Time |
| 8-24 | vs Meigs | 7 pm |
| 9-1 | vs River Valley | 7 pm |
| 9-7 | at Jackson | 7 pm |
| 9-14 | at Chesapeake | 7 pm |
| 9-21 | at Portsmouth | 7 pm |
| 9-28 | vs Fairland | 7 pm |
| 10-5 | at Coal Grove | 7 pm |
| 10-12 | vs Rock Hill | 7 pm |
| 10-19 | at Ironton | 7 pm |
| 10-26 | vs South Point | 7 pm |
River Valley Raiders
| Date | Opponent | Time |
| 8-24 | vs Coal Grove | 7:30 pm |
| 9-1 | at Gallia Academy | 7 pm |
| 9-7 | vs Portsmouth | 7:30 pm |
| 9-14 | vs Nelsonville-York | 7:30 pm |
| 9-21 | at Meigs | 7:30 pm |
| 9-28 | vs Wellston | 7:30 pm |
| 10-5 | at Alexander | 7:30 pm |
| 10-12 | vs Vinton County | 7:30 pm |
| 10-19 | at Athens | 7:30 pm |
| 10-27 | at South Gallia | 7:30 pm |
South Gallia Rebels
| Date | Opponent | Time |
| 8-25 | at Symmes Valley | 7 pm |
| 8-31 | vs Waterford | 7:30 pm |
| 9-7 | at Federal Hocking | 7 pm |
| 9-14 | vs Trimble | 7:30 pm |
| 9-21 | at Eastern | 7:30 pm |
| 9-28 | at Southern | 7:30 pm |
| 10-5 | vs Belpre | 7:30 pm |
| 10-12 | at Wahama | 7:30 pm |
| 10-19 | vs Miller | 7:30 pm |
| 10-27 | vs River Valley | 7:30 pm |
Ohio Bobcats
| Date | Opponent | Time |
| 9-1 | vs Howard | 2 p.m. |
| 9-15 | at Virginia | 3 p.m. |
| 9-22 | at Cincinnati | TBA |
| 9-29 | vs Massachusetts | TBA |
| 10-6 | at Kent State | 3:30 |
| 10-13 | at Northern Illinois | 3:30 |
| 10-20 | vs Bowling Green | 2 p.m. |
| 10-25 | vs Ball State | 7 p.m. |
| 11-1 | at Western Michigan | 7 p.m. |
| 11-7 | at Miami of Ohio | TBA |
| 11-14 | vs Buffalo | TBA |
| 11-23 | vs Akron | TBA |
Meigs Marauders
| Date | Opponent | Time |
| 8-24 | at Gallia Academy | 7 pm |
| 9-1 | at St. Clairsville | 7 pm |
| 9-7 | vs Logan | 7:30 pm |
| 9-14 | at Vinton County | 7:30 pm |
| 9-21 | vs River Valley | 7:30 pm |
| 9-28 | at Nelsonville-York | 7:30 pm |
| 10-5 | vs Athens | 7:30 pm |
| 10-12 | vs Point Pleasant | 7:30 pm |
| 10-19 | vs Wellston | 7:30 pm |
| 10-26 | at Alexander | 7:30 pm |
Southern Tornadoes
| Date | Opponent | Time |
| 8-24 | vs Portsmouth ND | 7:30 pm |
| 8-31 | vs Federal Hocking | 7:30 pm |
| 9-7 | at Wahama | 7:30 pm |
| 9-14 | vs Miller | 7:30 pm |
| 9-21 | at Belpre | 7:30 pm |
| 9-28 | vs South Gallia | 7:30 pm |
| 10-5 | at Ravenswood | 7:30 pm |
| 10-12 | at Waterford | 7:30 pm |
| 10-19 | vs Trimble | 7:30 pm |
| 10-27 | at Eastern | 7 pm |
Eastern Eagles
| Date | Opponent | Time |
| 8-24 | vs Huntington Ross | 7:30 pm |
| 8-30 | at Caldwell | 7:30 pm |
| 9-7 | vs Trimble | 7:30 pm |
| 9-14 | at Waterford | 7:30 pm |
| 9-21 | vs South Gallia | 7:30 pm |
| 9-28 | at Wahama | 7:30 pm |
| 10-5 | at Federal Hocking | 7:30 pm |
| 10-12 | vs Miller | 7:30 pm |
| 10-19 | at Belpre | 7:30 pm |
| 10-27 | vs Southern | 7 pm |
Ohio State Buckeyes
| Date | Opponent | Time |
| 9-1 | vs Oregon St. | noon |
| 9-8 | vs Rutgers |
3:30 |
| 9-15 | at Texas Christian | 8 pm |
| 9-22 | vs Tulane | TBA |
| 9-29 | at Penn State | TBA |
| 10-6 | vs Indiana | TBA |
| 10-13 | vs Minnesota | TBA |
| 10-20 | at Purdue | TBA |
| 11-3 | vs Nebraska | TBA |
| 11-10 | at Michigan St. | TBA |
| 11-17 | at Maryland | TBA |
| 11-24 | vs Michigan | noon |
Point Pleasant Big Blacks
| Date | Opponent | Time |
| 8-24 | at Mingo Central | 7:30 pm |
| 8-31 | at South Harrison | 7:30 pm |
| 9-7 | vs Warren | 7:30 pm |
| 9-14 | vs Herbert Hoover | 7:30 pm |
| 9-21 | vs Pikeville (KY) | 7:30 pm |
| 9-28 | BYE-OPEN | —- |
| 10-5 | BYE-OPEN | —- |
| 10-12 | at Meigs | 7 pm |
| 10-19 | at Man | 7:30 pm |
| 10-26 | vs Spring Valley | 7:30 pm |
| 11-2 | vs James Monroe | 7:30 pm |
Wahama White Falcons
| Date | Opponent | Time |
| 8-24 | at Ravenswood | 7:30 pm |
| 8-31 | at Miller | 7:30 pm |
| 9-7 | vs Southern | 7:30 pm |
| 9-14 | vs Belpre | 7:30 pm |
| 9-21 | at Federal Hocking | 7:30 pm |
| 9-28 | vs Eastern | 7:30 pm |
| 10-5 | at Waterford | 7:30 pm |
| 10-12 | vs South Gallia | 7:30 pm |
| 10-19 | BYE | —- |
| 10-26 | at Trimble | 7:30 pm |
| 11-2 | vs Buffalo | 7:30 pm |
Hannan Wildcats
| Date | Opponent | Time |
| 8-24 | at Tug Valley | 7:30 pm |
| 8-31 | vs Green | 7:30 pm |
| 9-7 | at Manchester | 7:30 pm |
| 9-14 | vs Hundred | 7:30 pm |
| 9-21 | vs Van | 7 pm |
| 9-28 | BYE-OPEN | —- |
| 10-5 | BYE-OPEN | —- |
| 10-12 | at Montcalm | 7 pm |
| 10-19 | vs Buffalo | 7 pm |
| 10-26 | vs Pburg Catholic | 7 pm |
| 11-2 | at Tolsia | 7 pm |
Marshall Thundering Herd
| Date | Opponent | Time |
| 9-1 | at Miami of Ohio | 3:30 |
| 9-8 | vs Eastern Kentucky |
6:30 |
| 9-15 | at South Carolina | 7:30 |
| 9-22 | vs N.C. State | 7 p.m. |
| 9-29 | at Western Kentucky | 7:30 |
| 10-5 | vs Middle Tennessee | 7:30 |
| 10-13 | at Old Dominion | 3:30 |
| 10-20 | vs Florida Atlantic | 2:30 |
| 11-3 | at Southern Mississippi | 3 p.m. |
| 11-10 | vs Charlotte | 2:30 |
| 11-17 | vs Texas-San Antonio | 2:30 |
| 11-24 | at Florida International | noon |
